Polyphenols targeting multiple molecular targets and pathways for the treatment of vitiligo Front Immunol. 2024 Jul Vitiligo, an autoimmune pigment disorder, is characterized by the selective loss of melanocytes in the skin, leading to the appearance of discolored patches.
The main pathological mechanism is the destruction of melanocytes caused by CD8+ T cells, which is regulated by oxidative stress and immune dysfunction.
Vitiligo affects both physical health and psychological well-being, reducing the quality of life. Polyphenols have demonstrated efficacy in the management of various dermatological diseases through multiple pathways.